神经炎症是神经系统内发生的炎症反应，可由多种因素引发，并在多种神经退行性疾病、神经精神疾病和神经系统损伤中发挥重要作用。随着对神经炎症机制的深入研究，容积调节阴离子通道（volume-regulated anion channel,VRACs)作为细胞膜的重要组成部分，逐渐被认为在神经系统的炎症反应中发挥了关键作用。本文综述了VRACs在神经炎症中的最新研究进展，探讨了其在神经元和胶质细胞中的功能及其与炎症因子的相互作用。通过分析VRACs的生理特性、调控机制及其在各种神经疾病中的作用，为理解神经炎症的发病机制提供了新的视角，并展望了未来的研究方向。
Neuroinflammation is an inflammatory response that occurs within the nervous system, triggered by various factors, and plays a significant role in various neurodegenerative diseases, neuropsychiatric disorders, and nervous system injuries.Recent studies on neuroinflammation mechanisms have shown that volume-regulated anion channels (VRACs), important components of cell membranes, play a key role in the nervous system's inflammatory response. This paper reviews recent research on VRAC channels in neuroinflammation, focusing on their functions in neurons and glial cells and their interactions with inflammatory factors. We analyze the physiological properties and regulatory mechanisms of VRAC channels and their roles in neurological diseases, offering new insights into neuroinflammation's pathogenesis and suggesting future research directions.
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