This case report reviews the course of a 67-year-old male patient who needed long-term intravenous chemotherapy for anti-tumor treatment of pancreatic cancer with peripheral mesenchymal implant metastasis, and developed thoracic outlet syndrome after receiving totally implantable venous access device (TIVAD) implantation. The patient developed right upper extremity edema after the operation, and the symptoms of edema could not be relieved after antithrombotic treatment and removal of the TIVAD. Proximal stenosis of the right subclavian vein was found by digital subtraction angiography(DSA) venography and the diagnosis of thoracic outlet syndrome was finally confirmed. Afrer implantation of a vascular stent at the stenosis, the symptoms were significantly relieved. The purpose of reporting this case is to emphasize the importance of regular follow-up of patients with TIVAD implantation, and to remind clinicians to adjust their clinical decisions according to the changes in the condition of the patients when they develop new symptoms, so as to ensure the safety of the patients and the therapeutic effect of the treatment.