[Abstract] Objective To investigate the effects of Sugammadex on deep neuromuscular blockade recovery and coagulation function in patients undergoing laparoscopic radical gastrectomy. Methods This study was a prospective study.Two hundred and twenty-six patients, aged 18-65 years, with BMI 18.5~27.9 kg/m2,American Society Anesthesiologists grade Ⅰ or Ⅱ,undergoing elective laparoscopic radical gastrectomy in Shanxi Province Cancer Hospital from May 2023 to May 2024, were randomly divided into neostigmine combined with atropine group (group N,n=113) and sugammadex group (group S,n=113) by a random number table method.Patients in both groups received intravenous infusion of propofol , intermittent intravenous infusion of sufentanil and rocuronium for general anesthesia induc-tion and maintenance, and controlled analgesia was connected with intravenous an-algesia pump after operation.During the operation,the bispectral index(BIS) was used to monitor the depth of anesthesia,and the neuromuscular block was assessed with a train-of-four(TOF) stimulus.At end of the surgery, when TOF count ≥2, pa-tients in group N received intravenous neostigmine 0.05mg/kg combined with atro-pine 0.02mg/kg, and patients in group S received intravenous sugammadex 2mg/kg.The time from the administration of neuromuscular blockade antagonists to extubation,and the time from the administration of neuromuscular blockade antagonists to recovery of TOF ratio≥0.9, and the time of post-anesthesia-care-unit (PACU) stay were recorded in both groups.At these time points: after admission (T0), before anesthesia induction (T1), before administration of muscle relaxant antagonists (T2), 1min after administration of muscle relaxant antagonists (T3), 5min after admin-istration of muscle relaxant antagonists (T4), and 30min after extubation (T5), the mean arterial pressure (MAP) and heart rate (HR) were recorded.The coagulation function of patients was monitored after entry (T0), 30min after extubation (T5) and 24H after operation (T6).The occurrence of PACU hypoxemia and pulmonary complications 7 days after operation were recorded. Results Compared with group N, the time to extubation and the time to restore TOFr≥0.9 were shortened significantly in group S.The MAP and HR of patients in group N were higher than those in group S at T3、T4。There was no significant difference in coagulation function between the two groups. The length of stay in PACU was shorter in group S There was no significant difference in pulmonary complications 7 days after operation Conclusion Sugammadex can reverse the residual neuromuscular blockade within shorter time in patients undergoing laparoscopic radical gastrectomy, and have no effect on coagulation function and postoperative pulmonary complications.