Stroke-induced cardiovascular dysregulation holds significant scientific and clinical relevance in elucidating the complexity of brain-heart interactions. Extensive clinical data substantiate that stroke can precipitate a spectrum of cardiovascular dysfunctions, including, but not limited to, arrhythmias, impaired myocardial pump function, and hemodynamic instability, which adversely affect patient prognosis and are closely associated with increased mortality rates. The term brain-heart axis refers to the intricate bidirectional functional network interconnecting the heart and the brain. This review aims to synthesize recent findings from in vitro studies to delineate the pathophysiological mechanisms of brain-heart interaction after cerebral ischemic stroke and to propose protective strategies for cardio-cerebral organs following stroke.