国际麻醉学与复苏杂志   2025, Issue (7): 0-0
    
妊娠期糖尿病对子代认知功能影响的研究现状
王帅夫, 赵平1()
1.中国医科大学附属盛京医院
Research Status of the Effects of Gestational Diabetes Mellitus on Offspring Cognitive Function
 全文:
摘要:

妊娠期糖尿病(Gestational Diabetes Mellitus,GDM)是妊娠期间常见的并发症。美国糖尿病协会将妊娠期糖尿病定义为在妊娠期间(通常在第24周左右)发病或首次发现的一种葡萄糖不耐受,其特点包括:1.可以在分娩后恢复正常的糖耐量异常;2.在妊娠前未被诊断的或是与妊娠同时发生的糖尿病。母体糖尿病的胎儿环境主要以高血糖,慢性缺氧和铁缺乏为特征,这种血糖的改变可能会影响胎儿的神经发育,对后代的认知有很大的影响。因此,明确GDM对子代认知功能的影响有着十分重要的意义。本文从临床试验、基础实验、建模以及机制的角度,着重阐述GDM对子代认知功能影响的研究现状。

关键词: 妊娠期糖尿病;子代;认知功能
Abstract:

Gestational Diabetes Mellitus (GDM) is a common complication of pregnancy. The American Diabetes Association defines gestational diabetes as the onset or first detection of glucose intolerance during pregnancy (usually around the 24th week),characterized by impaired glucose tolerance that normalizes after childbirth and diabetes mellitus that was not diagnosed prior to pregnancy or that occurred concurrently with pregnancy. The fetal environment of maternal diabetes is primarily characterized by hyperglycemia, chronic hypoxia, and iron deficiency, such changes in blood glucose may affect fetal neurodevelopment and has a great impact on the recognition of offspring. Therefore, it is of great significance to clarify the effects of GDM on the cognitive function of offspring. From the perspectives of clinical trials, lab experiments, modeling and mechanisms, this paper focuses on the research status of the effects of GDM on offspring cognitive function.

Key words: Gestational Diabetes Mellitus; Offspring; Cognitive function