ABSTRACT Objective: To investigate the application of pulse pressure variability combined with low central venous pressure monitoring in hepatic hydatidiectomy. Methods: 50 patients undergoing elective liver hydatidid resection in our hospital from April 2020 to February 2024 were selected for study, 25 patients in observation group (pulse pressure variability combined with central venous pressure monitoring group) and 25 patients in control group (conventional anesthesia group). Compared the intraoperative blood loss, hilar block time, hepatic hydatid resection time, preoperative and postoperative arterial blood gas indexes and liver and kidney function indexes before and after 1d in the two groups. Results: Compared with the two groups, the observation group was significantly less than the control group, and the liver portal blocking time and hydatid resection time in the observation group were significantly shortened, statistically different (P 0.05); the lactate levels in the two groups were increased, and the hemoglobin and hematocrit levels decreased (P 0.05), and the lactate, hemoglobin and hematocrit levels in the observation group were significantly different (P 0.05). The liver function and renal function indexes of both groups were significantly higher than the postoperative glutamate transaminase (ALT) level (P 0.05), but the increase in the observation group was significantly lower than that of the control group (P 0.05). There was no statistical difference in total bilirubin (TBIL), blood urea nitrogen (BUN) and blood creatinine (Scr) at 1d (P 0.05). Conclusion: Pulse pressure variation combined with low central venous pressure monitoring can significantly reduce the amount of intraoperative blood loss, reduce the time of hepatic portal block, shorten the time of hepatic hydatid resection, and have no obvious impact on postoperative liver and kidney function, which can be safely used in clinical practice.