Sepsis is a disease characterized by high morbidity and mortality due to dysregulation of the immune response to infection and resulting organ dysfunction. Specialized pro-resolving mediators (SPMs) are mediators derived from essential polyunsaturated fatty acids (PUFA) that exert pro-inflammatory effects by limiting neutrophil migration and infiltration, regulating inflammatory cytokine expression, and enhancing macrophage phagocytosis. It has a protective effect on organ damage such as myocardial, pulmonary, renal, hepatic and cerebral damage caused by sepsis and has potential clinical value for the treatment of sepsis. This article provides a review of the role and mechanism of SPMs in sepsis induced multiple organ dysfunction.