Objective To investigate the effect of ultrasound‑guided superficial cervical plexus block (SCPB) on postoperative quality of recovery in patients undergoing microvascular decompression (MVD). Methods A total of 60 patients with hemifacial spasms (HFS) who were scheduled for microvascular decompression were selected. According to the random number table method, they were divided into two groups (n=30): a SCPB group and a general anesthesia group. Patients in the SCPB group underwent ultrasound‑guided SCPB on the surgical side in combination with general anesthesia, while those in the general anesthesia group received general anesthesia alone. Both groups were given the same general anesthesia protocols. Their general information was recorded. The 40‑item Quality of Recovery Score (QoR‑40) was recorded at postoperative 24 h. The Numerical Rating Scale (NRS) scores at rest and during movement were recorded at postoperative 1, 6, 24 h and 48 h. The rate of rescue analgesia was assessed at different time points after surgery: T1 (00.05). Compared with the general anesthesia group, the SCPB group showed increases in QoR‑40 scores for pain, physical comfort, emotional state, and total score at postoperative 24 h (all P<0.05), decreases in the intraoperative doses of remifentanil (P<0.05), decreases in NRS scores at rest and during movement at postoperative 1, 6 h and 24 h (all P<0.05), decreases in the rate of rescue analgesia at T1 and T2 (all P<0.05), and decreases in the incidence of severe pain at postoperative 48 h (P<0.05). There were no statistical differences in other indexes between the two groups (all P>0.05). No nerve block‑related complications occurred in the SCPB group. Conclusions Compared with general anesthesia alone, the combination of ultrasound‑guided SCPB and general anesthesia can improve postoperative quality of recovery in patients undergoing MVD, relieve postoperative pain, reduce the rates of rescue analgesia, decrease the incidence of severe pain, and promotes enhanced recovery.