翻译后修饰（PTM）是调控各种细胞生物过程中重要的表观遗传机制，在免疫调节和维持体内平衡方面发挥重要作用。乳酸代谢以及由乳酸介导的组蛋白乳酸化修饰参与多种肺部疾病的病理生理过程。了解PTM在肺部疾病中的作用机制对于发现新的治疗靶点非常重要，也为更好地理解肺部疾病的发生、发展提供了进一步的证据。文章总结了乳酸代谢及乳酸化修饰在呼吸系统肿瘤与非肿瘤疾病中的机制及通路，阐述了可能存在的靶向治疗位点，旨在研究乳酸化修饰与肺部疾病的相关性并期望开发潜在的治疗策略，从而加速该研究从实验室向临床工作的转化。
Post‑translational modification (PTM) are important epigenetic mechanisms in the regulation of various cellular biological processes, playing a significant role in immune regulation and the maintenance of homeostasis. Lactate metabolism and lactate‑mediated modification of histone through lactylation are involved in the pathophysiological processes of several lung diseases. Understanding the mechanism of action of PTM in lung diseases is crucial for the discovery of new therapeutic targets and contributes to a better understanding of the development of lung diseases. This review summarizes the mechanisms and pathways of lactate metabolism and lactation modification in both oncological and non‑oncological respiratory diseases. It also describes potential therapeutic targets and aims to investigate the relevance of lactation modification in lung diseases, to develop therapeutic strategies that could facilitate the translation of this research from the laboratory to clinical settings.
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