Alzheimer's Disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory loss, with clinical manifestations of reduced cognitive and learning abilities, which imposes a heavy burden on families and society. Numerous clinical and basic research have shown that sleep disorders lead to cognitive decline and are risk factors for AD. This paper is to review the mechanisms by which sleep disorders exacerbate the deposition of amyloid-β and aggregation of tau associated with AD.