Neuraxial labor anesthesia is the safest and most effective way to relieve labor pain. Programmed intermittent epidural bolus (PIEB) is considered a more ideal mode of intrathecal labor analgesia drug delivery than the traditional continuous epidural infusion (CEI). However, optimal parameter settings for PIEB have not yet been conclusively determined. This review summarizes and encapsulates the current domestic and international research advances in PIEB parameters set in the application of intrathecal labor analgesia, including bolus volume, inter‑bolus interval, infusion rate, and so on. It aims to provide references for better rational and safe clinical application of PIEB and to suggest new perspectives and directions for future researchers.