国际麻醉学与复苏杂志   2024, Issue (9): 0-0
    
扁桃体/腺样体切除术患儿苏醒期谵妄的危险因素分析
冯蓓, 杨晓霞, 高宇博1()
1.宁夏医科大学总医院麻醉与围术期医学科
Analysis of risk factors for emergence delirium after tonsillectomy/adenoidectomy in preschool children
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摘要:

目的 分析扁桃体/腺样体切除术患儿苏醒期谵妄的危险因素。 方法 选取2022年11月—2023年9月于宁夏医科大学总医院行扁桃体/腺样体切除术的94例患儿,根据术后是否发生苏醒期谵妄分为谵妄组(19例)和非谵妄组(75例)。比较两组患者一般资料及术前实验室参数,对组间比较差异有统计学意义的变量[年龄、淋巴细胞计数、中性粒细胞/淋巴细胞、单核细胞/淋巴细胞、改良耶鲁术前焦虑量表(mYPAS)评分、术后儿童疼痛行为量化评分表(FLACC)评分]进行单因素logistic回归分析,将单因素logistic回归分析中P<0.05的变量纳入多因素logistic回归分析,分析扁桃体/腺样体切除术患儿苏醒期谵妄的独立危险因素。 结果 94例患儿中有19例(25.3%)发生苏醒期谵妄。谵妄组患儿年龄低于非谵妄组,mYPAS评分、术后FLACC评分>4分的比例高于非谵妄组,术前淋巴细胞计数高于非谵妄组,术前中性粒细胞/淋巴细胞、单核细胞/淋巴细胞低于非谵妄组(均P<0.05);其余一般资料及术前实验室参数差异无统计学意义(均P>0.05)。单因素logistic回归分析结果显示,年龄小[比值比(OR) 0.66,95%置信区间(CI) 0.445~0.991,P<0.05]、术前淋巴细胞计数高(OR 1.57,95%CI 1.026~2.402,P<0.05)、mYPAS评分高(OR 1.03,95%CI 1.004~1.057,P<0.05)、术后FLACC评分>4分(OR 5.95,95%CI 1.797~19.687,P<0.05)为扁桃体/腺样体切除术患儿苏醒期谵妄的危险因素。多因素logistic回归分析显示,术后FLACC评分>4分(OR 5.32,95%CI 1.470~19.232,P<0.05)是扁桃体/腺样体切除术患儿苏醒期谵妄的独立危险因素。 结论 扁桃体/腺样体切除术患儿苏醒期谵妄发生率为25.3%。FLACC评分>4分是扁桃体/腺样体切除术患儿苏醒期谵妄的独立危险因素。

关键词: 学龄前期; 儿童; 扁桃体/腺样体切除术; 苏醒期谵妄; 危险因素
Abstract:

Objective To analyze the risk factors of emergence delirium in children after tonsillectomy/adenoidectomy. Methods A total of 94 children who underwent tonsillectomy/adenoidectomy at Ningxia Medical University General Hospital from November 2022 to September 2023 were selected and divided into a delirium group (n=19) and a non‑delirium group (n=75) according to whether postoperative delirium occurred during the recovery period. Comparing the general information and preoperative laboratory parameters of the two groups of patients, variables with statistically significant differences between the groups [age, lymphocyte count, neutrophils/lymphocytes, monocytes/lymphocytes, modified Yale Preoperative Anxiety Scale (mYPAS) score, postoperative Pain Behavior Quantification Scale for Children (FLACC) score] were subjected to single‑factor logistic regression analysis, and variables with P<0.05 in the single‑factor logistic regression analysis were included in the multi‑factor logistic regression analysis. Analysis of independent risk factors for emergence delirium in children undergoing tonsillectomy/adenoidectomy. Results Nineteen out of 94 children (25.3%) developed emergence delirium. The age of the children in the delirium group was lower than that of the non‑delirium group, the proportion of mYPAS score and postoperative FLACC score>4 points was higher than that of the non‑delirium group, the preoperative lymphocyte count was higher than that of the non‑delirium group, and the preoperative neutrophil/lymphocyte count was higher than that of the non‑delirium group. The numbers of neutrophils/lymphocytes and monocytes/lymphocytes in the blood of patients in the delirium group are lower than those numbers in patients in the non⁃delirium group (all P<0.05). There were no statistically significant differences in other general information and preoperative laboratory parameters (all P>0.05). The results of single‑factor logistic regression analysis showed that young age [odds ratio (OR) 0.66 (95% confidence interval (CI) 0.445, 0.991), P<0.05] and high lymphocyte count [OR 1.57 (95%CI 1.026, 2.402), P<0.05], high mYPAS score [OR 1.03 (95%CI 1.004, 1.057), P<0.05], and postoperative FLACC score>4 points [OR 5.95 (95%CI 1.797, 19.687), P<0.05] are tonsil/ Risk factors for emergence delirium in children undergoing adenoidectomy. Multivariate logistic regression analysis showed that postoperative FLACC score>4 points [OR 5.32 (95%CI 1.470, 19.232), P<0.05] is an independent risk factor for emergence delirium in children undergoing tonsillectomy/adenoidectomy. Conclusions The incidence of emerging delirium in children who underwent tonsillectomy/adenoidectomy was 25.3%. FLACC score>4 is an independent risk factor for emergence delirium in children undergoing tonsillectomy/adenoidectomy.

Key words: Preschool stage; Child; Tonsillectomy; Emergence delirium; Risk factor