国际麻醉学与复苏杂志   2025, Issue (3): 0-0
    
术前睡眠质量与老年患者胸科手术术后谵妄的相关性研究
刁萌萌, 王涵, 张书芮, 焦皓1()
1.徐州医科大学
Correlation between preoperative sleep quality and postoperative delirium in elderly patients undergoing thoracic surgery
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摘要:

目的 通过多变量Logistic回归分析,研究术前睡眠质量对老年胸部手术患者术后谵妄(postoperative delirium,POD)的影响,以及与术后谵妄发生相关的危险因素。方法 这是一项单中心、前瞻性、队列研究。根据研究标准,于2022年7月~12月在徐州医科大学附属医院纳入择期行胸科手术的60岁以上患者210例。术前1天使用匹兹堡睡眠质量评分(pittsburgh sleep quality index,PSQI),将患者分为睡眠正常组(H组,PSQI≤5分),睡眠障碍组(L组,PSQI>5分),每组105例患者。每组均采用常规统一麻醉管理,术后均使用静脉镇痛泵。记录一般资料,及手术时间、术中静脉麻醉药用量、术中低血压和低氧血症发生率、术后不同时段的视觉疼痛评分(visual analogue scale/score, VAS)和恢复质量(QoR-15)、术后镇痛泵按压总次数、术后住院时长、术后30天内再次住院治疗次数。探究术前睡眠质量与术后谵妄之间的相关性,并采用多因素Logistic回归多种因素对于老年人接受胸科手术后POD的风险的影响。结果 两组共有31例(30.1%)在术后发生POD。L组POD发生率比H组高,差异无统计学意义,但持续时间明显更长(P<0.05);L组拔管后15-30min、术后24h的VAS评分明显高于H组(P<0.05);术后24h,L组的QoR-15总分明显低于H组(P 0.05)。结论 术前睡眠障碍增加了老年胸科患者POD的发生率,对术后早期疼痛和恢复质量产生负面影响,麻醉科和临床科室应予以重视。

关键词: 睡眠障碍;睡眠质量;术后谵妄;老年患者;胸科手术
Abstract:

Objective To investigate the effect of preoperative sleep quality on the development of postoperative delirium (POD) in elderly patients undergoing thoracic surgery and the risk factors associated with the development of postoperative delirium through multivariate logistic regression analysis. Methods This is a single-centre, prospective, cohort study. According to the study criteria, 210 patients aged 60 years or older who underwent elective thoracic surgery in the Department of Thoracic Surgery at the Affiliated Hospital of Xuzhou Medical University from July to December 2022. The Pittsburgh Sleep Quality Index (PSQI) was used to divide the patients into a normal sleep group (Group H, PSQI ≤ 5) and a sleep disorder group (Group L, PSQI 5), with 105 patients in each group. Each group was managed with Conventional uniformity anaesthesia and postoperatively with an intravenous analgesic pump. General information was recorded, as well as the duration of surgery, intraoperative intravenous anaesthetic dosage, incidence of intraoperative hypotension and hypoxaemia, visual pain score (VAS) and quality of recovery (QoR-15) at different postoperative times, total number of postoperative analgesic pump compressions, length of postoperative hospital stay, and number of readmissions within 30 days after surgery. Independent risk factors for the occurrence of POD were analysed using multifactorial logistic regression. Results A total of 31 cases (30.1%) in both groups developed POD postoperatively. the incidence of POD was higher in the L group than in the H group. The difference was not statistically significant, but the duration was significantly longer (P 0.05); the VAS scores 15-30 minutes after extubation and 24 hours after surgery were significantly higher in group L than in group H (P 0.05); the total QoR-15 score at 24 hours after surgery was significantly lower in group L than in group H (P 0.05). Conclusion Preoperative sleep disturbances increase the incidence of POD in elderly thoracic patients, negatively impacting on early postoperative pain and quality of recovery, and should be taken into account by anaesthesia and clinical departments.

Key words: Sleep disturbances; Sleep quality; Postoperative delirium; Elderly patients; Thoracic surgery