Ｏｂｊｅｃｔｉｖｅ　To observe abnormal coagulation in glioma patients during perioperative period, and provide evidence for the prevention and control of postoperative hemorrhage and thrombosis risks related complications in glioma patients.　Methods　Prospective studies were performed using pre-operative information and coagulation results from glioma patients in Beijing Tiantan Hospital, Capital Medical University. Meanwhile, the coagulation function was detected by thromboelastogram (TEG). The incidences of intracranial hemorrhage and venous embolism after surgery were recorded. The patients with or without postoperative coagulation-related complications were compared. The risk factors were analyzed according to Logistic regression analysis.　Results　A total of 141 glioma patients treated by surgery were enrolled, including 28 patients with coagulation-related complications and 113 patients without the complications. Compared with patients without coagulation complications, those with post-operative complications had higher ages [(47±17) vs (35±19), P=0.003], increased volumes of colloid fluid used during surgery (100% vs 93%, P=0.014), increased proportion of advanced grade glioma (71% vs 30%, P=0.003), longer hospitalization stay (19 d vs 15 d, P=0.008）and longer duration of perioperative dehydration treatment (12.0 d vs 10.5 d, P=0.017). According to logistic regression analysis, age [odds ratio (OR)=1.033, P=0.026], high-grade glioma (OR=3.173, P=0.031), abnormal preoperative coagulation functions and perioperative TEG (OR=4.332, P=0.028), and the volume of colloid fluid used (OR=2.857, P=0.032) were the risk factors of postoperative coagulation complications.　Conclusions　A combination of rapid TEG monitoring of coagulation function during tumor resection and preoperative standard coagulation function (SCTs) is useful to identify patients with high risks of coagulation-related complications after surgery.