Ｏｂｊｅｃｔｉｖｅ　We discussed the influencing factors on deep vein thrombosis formation on patients with traumatic brain injury.　Methods　A retrospective study was conducted among 289 traumatic brain injury patients who underwent craniotomy procedures at Beijing Tiantan Hospital, Capital Medical University from January 2016 to December 2018. Among them, 47 patients suffered deep vein thrombosis after surgery. We analyzed the influencing factors on deep vein thrombosis formation using multi-factor Logistic analysis.　Results　Multivariate logistic regression analysis revealed that preoperative Glasgow Coma Scale　（GCS）<10 [P=0.004, odds ratio (ＯR)=1.359, 95% ｃonfidence interval (CI) 1.101-1.677], prothrombin time<12.0 s (P=0.029, OR=1.945, 95%CI 1.216-2.341), subarachnoid hemorrhage(P=0.013, OR=2.030, 95%CI 1.502-2.781) and operative time>3.1 h (P=0.040, OR=3.171, 95%CI 2.031-3.922) are factors that may influence deep veins thrombosis in traumatic brain injury patients.　Conclusions　For traumatic brain injury patients who have lower GCS, shorter prothrombin time, subarachnoid hemorrhage and prolonged surgery duration, clinicians should pay attention to the incidence of deep vein thrombosis.