Perioperative coagulation dysfunction is very common in patients with brain tumor, which increases the risks of intracranial hemorrhage and venous thromboembolism and other serious complications, and greatly extends treatment duration and medical costs. This paper analyzes and summarizes the progress in coagulation dysfunction and monitoring in patients undergoing brain tumor surgery, so as to provide evidence for perioperative prevention, control and management. The paper briefly introduces the incidence, risk factors, mechanisms and prevention and control and treatment of coagulation dysfunction in patients with brain tumors during perioperative period. It′s necessary to closely monitor the dynamic changes of coagulation function, recognize the related risk factors and make individual management scheme in patients with brain tumors during perioperative period, so as to reduce coagulation-related complications and promote early recovery of patients.