Ｏｂｊｅｃｔｉｖｅ　The present research was designed to explore the role of transient receptor potential vanilloid 1(TRPV1) in analgesia induced by enflurane(Enf) and sevoflurane(Sev).　Methods　Two hundred and forty mice were completely randomly divided into intraperitoneally (ip) (hot-plate test) or subcutaneously (SC) (acetic acid-induced writhing test) saline and Enf, Sev groups and each group according to intrathecal injection solvent and capsaicin (2.5, 5, 10 ng) was divided into four subgroups. After established the mice model of analgesia by intraperitoneal or subcutaneous injection of appropriate doses of Enf or Sev, we injected different doses of capsaicin intrathecally and observed effects on the pain threshold using the hot-plate and acetic acid-induced writhing test.　Results　The results showed that intrathecal injection of capsaicin(2.5, 5, 10 ng) did not affect the pain threshold in hot-plate test(HPPT) or the writhing numbers in conscious mice(P>0.05). In contrast, capsaicin (2.5, 5, 10 ng intrathecally) was signiflcantly decreased the HPPT and increased the writhing nubmers［Enf group: (22±7), (24±5), (29±6) vs (16±6), Sev group: (21±6), (23±7), (28±4) vs (13±5)］ in mice treated with Enf or Sev(P<0.05).　Conclusions　These results suggest that spinal TRPV1 may mediate the analgesic effects of Enf and Sev.