Background　Pannexin(Panx)1 belongs to Panx family and has been regarded as a group of newly discovered gap junction proteins. Panx1 is ubiquitously expressed on various cell types and is involved in the transportation of intracellular metabolites and signal transmitters.　Objective　This review aims to discuss the role of Panx1 in the inflammatory responses and immune responses of sepsis as well as its therapeutic potentials as a new target for sepsis treatment.　Content　This review discusses Panx1 as a key player mediating ATP release from apoptotic and dying cells in the activation of innate and adaptive immune response, particularly its pathophysiological relations to the development of sepsis. Furthermore, pharmacological inhibition of Panx1 by using small molecules for the treatment of sepsis is highlighted.　Trend　Panx1 is pathophysiologically linked to a variety of diseases such as inflammation, seizure and cancer. Emerging evidences also reveal a critical role of Panx1 in sepsis, making Panx1 a promising therapeutic candidate for sepsis treatment.