Ｏｂｊｅｃｔｉｖｅ　To observe the application of goal-directed therapy（GDT） directed by transesophageal echocardiography（TEE） in patients of cutting colon cancer operation.　Methods　Sixty scheduled colon cancer patients with epidural plus general anesthesia were randomly divided into routine fluid therapy group（group C） and GDT group monitered with TEE（group T） using random digits table（n=30）. The patients of group C were infused routinely after anesthesia， the patients of group T were infused under monitered stroke volume（SV） and corrected left ventricular ejection time（LVETc） with TEE. Mean artery pressure（MAP）， heart rate （HR）， the amount of infused fluid ， central venous pressure （CVP） of two groups were recorded before anesthesia （T1）， tracheal intubation （T2）， the time point of abdomen exploration （T3）， cuting goiter （T4）， closing abdomen （T5） and after extubation（T6）. The total amount of infusion fluid and urine volume were recorded at the end of operation. The plasma amount of D-lactic acid were monitered at the time point of preoperation， after cuting goiter and the end of operation. Postoperation time of air bleed ，defecate Liquid Diet were monitored. Postoperative nausea emesia， various complications， the time to take food， hospital day were observed.　Results　The MAP and HR of T2 and T3 were lower than before anesthesia（P<0.01）， there were no significant difference among other time. The CVP of all groups at T2 were higher than T1， the CVP of group T was higher than group C at the point of T4，T5 and T6（P<0.01）. There were significantly diffferent between two groups about amount of fluid replacement at the time point of T3，T4，T5 and T6（P<0.05）. The urine volume of group T was less than that of group C. There were no significant difference about LAC between two groups. The morbidity of nausea of C group ［（4.7±0.3） d］ was higher than group T［（3.2±0.7） d］（P<0.05）. The air bleed， defecate time of group T ［（2.84±0.14） d］ were significant shorter than group C ［（3.95±0.72） d］（P<0.05）， liquid diet time of group T ［（4.5±0.9） d］ was earlier than group C ［（5.9±0.7） d）］（P<0.05）， the incidence of postoperative nausea and vomiting and the inhospital day of group T ［13%, （8.2±3.4） d］ was less than that of group C［30%, （11.3±2.3） d）］（P<0.05）.　Conclusions　GDT provides obviously dominant postoperative outcome for patients with operation of cutting colon cancer.