[Abstract] Objective To investigate the effects of pregabalin on the postoperative analgesia in patients with lower abdominal surgery. Methods: The patients aged 19-70, ASA I-II, scheduled for lower abdominal surgery were randomly divided into 2 groups (n=15): Group P (pregabalin) and Group C(control). The patients in Group P and C orally took pregabalin (75 mg) or self-made flour capsule 30 min prior to general anesthesia, respectively. General anesthesia was routinely induced and maintained with remifentanil, propofol and muscle relaxant. The patient-controlled intravenous analgesia(PCIA) was used in every patient. The rest pain and cough pain was assessed using vision analogue scale （VAS）at 2, 4, 8, 12, 20 and 24 h after surgery,respectively. The effective and total numbers of PCIA, analgesic comsuption and side-effects were recorded in postoperative 24h. Results All 30 patients completed the trial. Compared with postoperative 2h postoperative 4,8,12,20,24 h, the the PCIA effective frequency and the total number of difference was statistically significant ( P <0.05 ) . Compared with group C [(6.3±0.7)、(5.8±0.6)、(4.9±0.5)、(4.3±0.6)、(2.5±0.7)、(1.9±0.3)]and[(8.1±0.5)、(7.7±0.5)、(7.0±0.4)、(6.3±0.6)、(4.5±0.6)、(3.9±0.5)], VAS during rest[(5.3±0.5)、(4.5±0.6)、(3.7±0.6)、(2.5±0.8)、(1.4±0.5)、(0.8±0.4)]and cough[(7.3±0.6)、(6.5±0.7)、(5.5±0.5)、(4.6±0.8)、(3.3±0.5)、(2.9±0.4)] at each time point static rest pain and cough, pain VAS scores were lower than group C ( P <0.05 ) lower after point postoperation were lower( P <0.05).Postoperative effective frequency[(2.0±0.4)、(3.3±0.7)、(3.9±1.1)、(3.9±1.1)、(3.9±1.1)、(3.9±1.1)]and the total number[(2.5±0.7)、(3.9±1.0)、(4.5±1.4)、(4.5±1.4)、(4.5±1.4)、(4.5±1.4)]of PCIA were lower in group P than that in group C( P > 0.05 ). Only nausea and vomiting were observed as post operation side effects, and there was no significant difference between the two groups ( P > 0.05 ) . Conclusions Orally-taken pregabalin (75 mg) prior to anesthesia may improve the treatment of postoperative analgesia, reduce the consumption of analgestics with less side-effects and contribute to the patients’recovery.