The transurethral resection of prostate(TURP) syndrome is caused by excessive absorption of hypotonic bladder irrigating fluid. Excessive absorption of hypotonic fluid can result in hyponatremia, hyposmolality, water intoxication, respiratory and circulatory failure, etc. This case report described the management of cardiac arrest after TURP in a 73-years-old man with benign prostatic hyperplasia and bladder tumors. The patient developed ventricular fibrillation and cardiac arrest might be due to intraoperative hyperkalemia and hyponatremia. After cardiopulmonary-cerebral resuscitation and advanced life support, the patient was stabilized. Further analysis of the pathophysiological changes of TURP syndrome will be needed for its prevention and treatment