Objective To analyze the clinical effects of different therapy process to the patients with deep vein thrombosis (DVT) during reduction and internal fixation surgery of lower extremity closed fracture through retrospective study of 206 cases. Methods Retrospective study of 1402 patients with lower limb close fracture, 206 patients were found DVT by color doppler flow imaging (CDFI) in preoperative and were divided into four groups according to the choice of patients or their families. There were 13, 7, 6 and 180 patients in group Ⅰ, Ⅱ, Ⅲ, Ⅳ respectively. The patients in group Ⅰ received expectant treatments. The patients in group Ⅱ had chosen to have an operation after thrombolysis, but there were three patients failed. The patients in group Ⅲ had an operation after the filter of deep venous placed. The patients in group Ⅳ had requested surgery without any other treatment. Results ① There was significant difference in the average hospital stay among groups (groupⅠ＞groupⅡ＞groupⅢ＞groupⅣ, P<0.01 ). ②The surgical hemorrhage in groupⅡand group Ⅲ are more than that in group Ⅳ, and blood transfusion is needed. ③ There were four cases of complications such as lumbosacral region bedsore , urinary tract infection and pneumonia in group Ⅰ. ④ There were 122 cases (63.2%) finished the operation under combined spinal epidural anesthesia(CSEA), and 71 cases（36.8%） under tracheal intubation general anaesthesia(GA). Conclusions ① To operate for lower extremity closed fracture patients with deep vein thrombosis without preoperative treatment, there are more advantages such as shorter hospital stay, fewer complications and more satisfaction for the patients, but anesthesiologists will face more challenges because of more complicated clinical situations. ② There is more surgical hemorrhage because of preoperative thrombolysis treatment or placing filter of deep venous, and blood transfusion is needed. ③ Unilateral spinal anesthesia is more advantageous when bupivacaine was given in subarachnoid space by low dosages. The hemodynamic of the patient is more stable, the expenditure is lower and there is shorter PACU stay.