背景 缺血后处理（ischemic postconditioning, IPo）减轻器官缺血/再灌注损伤（ischemia reperfusion injury, I/RI）的效果确切，临床实用性强，成为近年来的研究热点。热休克蛋白（heat shock protein, HSP）是细胞应激反应的生物学标志及内源性保护蛋白，参与器官I/RI过程。目的 总结国内外对IPo与HSP在器官I/RI中作用的研究成果，为IPo器官保护机制的研究提供思路。内容 国内外学者研究证实IPo可以减轻多种器官的I/RI，并将其应用于临床，取得一定的疗效。HSP通过减轻再灌注过程中的氧化应激反应和炎症反应，减少细胞凋亡，保护细胞骨架的完整性,发挥细胞保护作用。趋势 IPo器官保护作用的机制研究应成为广大学者今后的研究方向，与其为临床应用提供理论基础。
Background Ischemia postconditioning(IPo) is an effictive and practical way to reduce ischemia/reperfusion organ injury(I/RI). It is becoming the hot spot of research recently. Heat shock proteins(HSP) is the biological marker of stress response and endogenous protective proteins, which are involved in the process of organ reperfusion injury. Objective To summarize the study progress of ischemic postconditioning and HSP in IRI and provide new ideas for further study. Content National and international studies have shown that IPo can reduce ischemia/reperfusion organ injury and it is being applied to the clinical settings. Heat shock proteins can attenuate oxidative stress responses and inflammatory reaction, reduce apoptosis, and protect the integrity of cytoskeleton in I/RI. Trend The protective mechanism of IPo should be further explored to provide the theoretical basis for its clinical application.
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