Background Stress response may be caused by severe burns, trauma, infection, surgery, etc. It mainly reflects hypermetabolic and systemic inflammatory responses, which. These responses usually increase the risk of infection and multiple organ dysfunction. Objective To reduce the metabolic disorder and inflammatory reaction through nutrition support. Content This paper reviewed the progress of nutritional therapy and provided strategies to manage the body of stress state. Trend Nutrition support plays a different part than before,finally there will be the best and most individual nutrition therapy for patients ,to reduce complication and improve the prognosis.