Objective To observe the application of sevoflurane,propofol sequence general anesthesia combine with Supreme laryngeal mask in the Cesarean section. Methods 60 cases parturient were randomly divided into sevoflurane,propofol sequence general combine with Supreme laryngeal mask group (group A) and infantile waist stiffness group (group B) with 30 cases each. Group A was administrated Supreme laryngeal-mask intubation after inhalation of (6-8)% sevoflurane in (5-8)L/min oxygen, then inhalation of (2-3)% sevoflurane in (2-3)L/min till the newborn delivery, and then used propofol combine with remifentanil to replace sevoflurane till the end of the operation. Group B was performed with spinal injection of ropivacaine9-12mg. The parturient undergone hypotension which could not recovered by fluid replacement was intravenous injection of ephedrine. To observe the time from anesthesia begin to operation begin, the volume of blood loss, the rate of low blood pressure and ephedrine to use, complication of anesthesia and Apgar scores at 0,5 and 10 minutes after delivery. RESULTS The time from anesthesia begin to operation begin was shorter in group A, the rate of low blood pressure, the rate of ephedrine to use and complication of anesthesia were lower in group A. The volume of blood loss and the Apgar scores at each time points were similar. CONCLUSION The effect of sevoflurane to the foetus is little and intravenous anesthesia replaced sevoflurane after the newborn delivery can reduce the effect of sevoflurane to the uterine contraction. And Supreme laryngeal mask can prevent back flow and aspiration efficiently. So the sevoflurane, propofol sequence general anesthesia combine with Supreme laryngeal mask is a comfortable and effective general anesthesia, which can apply in the Cesarean section safely.